ParkinsonCanadaV1, France, Analysis, bibRecord, 000286

Brain proteasomal function in sporadic Parkinson's disease and related disorders

Identifieur interne : 000286 ( France/Analysis ); précédent : 000285; suivant : 000287

Brain proteasomal function in sporadic Parkinson's disease and related disorders

Auteurs : Yoshiaki Furukawa [Canada] ; Sophie Vigouroux [France] ; Henry Wong [Canada] ; Mark Guttman [Canada] ; Ali H. Rajput [Canada] ; LEE ANG [Canada] ; Marièle Briand [France] ; Stephen J. Kish [Canada] ; Yves Briand [France]

Source :

Annals of neurology [ 0364-5134 ] ; 2002.

RBID : Pascal:02-0447146

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Sporadique, Multicatalytic endopeptidase complex, Encéphale, Anatomopathologie, Exploration, Autopsie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Autopsy, Brain (enzymology), Brain (physiology), Brain (vertebrata), Cysteine Endopeptidases (genetics), Cysteine Endopeptidases (metabolism), Exploration, Human, Humans, Multicatalytic endopeptidase complex, Multienzyme Complexes (genetics), Multienzyme Complexes (metabolism), Multiple System Atrophy (enzymology), Multiple System Atrophy (genetics), Parkinson Disease (enzymology), Parkinson Disease (genetics), Parkinson disease, Pathology, Peptide Hydrolases (metabolism), Proteasome Endopeptidase Complex, Sporadic, Supranuclear Palsy, Progressive (enzymology), Supranuclear Palsy, Progressive (genetics).
MESH :
- chemical , genetics : Cysteine Endopeptidases, Multienzyme Complexes.
- enzymology : Brain, Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- genetics : Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- chemical , metabolism : Cysteine Endopeptidases, Multienzyme Complexes, Peptide Hydrolases.
- physiology : Brain.
- Aged, Humans, Proteasome Endopeptidase Complex.

Abstract

Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.

Affiliations:

Links to Exploration step

Pascal:02-0447146

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Brain proteasomal function in sporadic Parkinson's disease and related disorders</title>
<author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurology, University of Saskatchewan</s1>
<s2>Saskatoon, Saskatchewan</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee Ang" sort="Lee Ang" uniqKey="Lee Ang" last="Lee Ang">LEE ANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology, University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>London, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0447146</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0447146 INIST</idno>
<idno type="RBID">Pascal:02-0447146</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000B63</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000160</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000A39</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A39</idno>
<idno type="wicri:doubleKey">0364-5134:2002:Furukawa Y:brain:proteasomal:function</idno>
<idno type="wicri:Area/Main/Merge">003548</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:12112087</idno>
<idno type="wicri:Area/PubMed/Corpus">001505</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001505</idno>
<idno type="wicri:Area/PubMed/Curation">001505</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001505</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001505</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001505</idno>
<idno type="wicri:Area/Ncbi/Merge">000239</idno>
<idno type="wicri:Area/Ncbi/Curation">000239</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000239</idno>
<idno type="wicri:doubleKey">0364-5134:2002:Furukawa Y:brain:proteasomal:function</idno>
<idno type="wicri:Area/Main/Merge">003421</idno>
<idno type="wicri:Area/Main/Curation">003099</idno>
<idno type="wicri:Area/Main/Exploration">003099</idno>
<idno type="wicri:Area/France/Extraction">000286</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brain proteasomal function in sporadic Parkinson's disease and related disorders</title>
<author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurology, University of Saskatchewan</s1>
<s2>Saskatoon, Saskatchewan</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee Ang" sort="Lee Ang" uniqKey="Lee Ang" last="Lee Ang">LEE ANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology, University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>London, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Autopsy</term>
<term>Brain (enzymology)</term>
<term>Brain (physiology)</term>
<term>Brain (vertebrata)</term>
<term>Cysteine Endopeptidases (genetics)</term>
<term>Cysteine Endopeptidases (metabolism)</term>
<term>Exploration</term>
<term>Human</term>
<term>Humans</term>
<term>Multicatalytic endopeptidase complex</term>
<term>Multienzyme Complexes (genetics)</term>
<term>Multienzyme Complexes (metabolism)</term>
<term>Multiple System Atrophy (enzymology)</term>
<term>Multiple System Atrophy (genetics)</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Pathology</term>
<term>Peptide Hydrolases (metabolism)</term>
<term>Proteasome Endopeptidase Complex</term>
<term>Sporadic</term>
<term>Supranuclear Palsy, Progressive (enzymology)</term>
<term>Supranuclear Palsy, Progressive (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cysteine Endopeptidases</term>
<term>Multienzyme Complexes</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brain</term>
<term>Multiple System Atrophy</term>
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Multiple System Atrophy</term>
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term>
<term>Multienzyme Complexes</term>
<term>Peptide Hydrolases</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Humans</term>
<term>Proteasome Endopeptidase Complex</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Sporadique</term>
<term>Multicatalytic endopeptidase complex</term>
<term>Encéphale</term>
<term>Anatomopathologie</term>
<term>Exploration</term>
<term>Autopsie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>France</li>
</country>
<region><li>Auvergne (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
</region>
<settlement><li>Clermont-Ferrand</li>
</settlement>
<orgName><li>Université Blaise-Pascal</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
</noRegion>
<name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<name sortKey="Lee Ang" sort="Lee Ang" uniqKey="Lee Ang" last="Lee Ang">LEE ANG</name>
<name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name>
</region>
<name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name>
<name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000286 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000286 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:02-0447146
   |texte=   Brain proteasomal function in sporadic Parkinson's disease and related disorders
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Brain proteasomal function in sporadic Parkinson's disease and related disorders

Brain proteasomal function in sporadic Parkinson's disease and related disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.